Oleanolic acid is widely found in plants, with a general content of 0.2%-2%. The content of Cucurbitaceae plant Luoguodi is 1.5%-2%, and the content of Ligustrum lucidum fruit is 0.6%-0.7%. Oleanolic acid is white acicular crystal (ethanol), odorless and tasteless. It is unstable to acid and alkali. Melting point 308-310 C, [alpha] 20D+73.3 degrees (c=0.15, chloroform), insoluble in water, soluble in methanol, ethanol, ether, acetone and chloroform
CAS No.: 508-02-1
EINECS NO: 208-081-6
|Appearance||White crystalline powder||Conform|
|Specific rotation||73.0 º-83.0 º||78.2 º|
|Loss on drying||≤0.5%||0.09%|
|Conclusion||The results conforms as Enterprise Standards|
- Oleanolic acid has anti-inflammatory, sedative, cardiac, diuretic, hypolipidemic, hypoglycemic and protective effects on liver and enzymes, enhancing immunity and inhibiting the growth of S180 tumor strain. It is an effective ingredient for the development and treatment of liver diseases and hypoglycemia. 2. Oleanolic acid has protective effect on chromosome damage and preventive effect on experimental atherosclerosis. Clinical use in the treatment of infectious acute jaundice hepatitis, chronic viral hepatitis, has a significant effect on reducing alanine aminotransferase and reducing jaundice. 3. Oleanolic acid can inhibit the proliferation of hepatic fibrosis. In rats with hepatic fibrosis treated with oleanolic acid, the proliferation of hepatic fibrosis is serious and significantly reduced, and the content of collagen in liver is reduced, suggesting that oleanolic acid can prevent and treat liver cirrhosis. 4. Reducing the level of brain homogenate tyrosine in cirrhotic rats: As the level of brain homogenate tyrosine decreased significantly, it could inhibit the production of pseudoneurotransmitters, so it was beneficial to the prevention and treatment of hepatic encephalopathy. 5. Oleanolic acid capsule is an over-the-counter drug used as an adjuvant drug for liver diseases, and is used as an adjuvant treatment for acute and chronic hepatitis. It has a certain protective effect on liver injury, can decrease the elevated serum alanine aminotransferase, promote the regeneration of hepatocytes, and accelerate the repair of necrotic tissues.
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